In addition to Manuel, those living on Mexico's Gulf Coast were recovering from the remnants of Hurricane Ingrid, and in the south, a storm system over the Yucatan Peninsula was likely to become a tropical cyclone.
On the Gulf Coast, in the state of Veracruz, Ingrid and its remnants claimed 11 lives. About 32,000 people had to be evacuated from their homes.
Residents there sent photos to CNN showing streets that looked like rivers, with the tops of cars sticking out of the floodwaters.
Another major concern in the Gulf Coast was that the new storm system brewing in the south could bring more rain to the already saturated area.
More than 1 million residents across Mexico have been affected in some way by the storms, Interior Minister Miguel Angel Osorio Chong told reporters.
In violence-ravaged state, another devastating blow
In Guerrero state, the storms were yet another devastating blow to a part of the country already suffering from some of the country's fiercest drug-related violence.
When government cleanup crews arrived in Renacimiento on Thursday, a security detail accompanied them.
Two pickup trucks circled the area, packed with heavily armed police officers wearing bullet-proof jackets.
A woman ran screaming out of her storm-battered home -- not because of the damage -- but because she learned her son had been kidnapped.
Nearby, Paulina Bravo and Teodoro Medina were cleaning up storm damage. Their house was still intact, but floodwaters destroyed their stove, refrigerator and beds.
"Now, my husband and I take turns sleeping in this hammock," Bravo said.
Two bags of bread, she said, are the only government aid she's received so far.
Bravo and her husband shoveled mud out of their home, determined to clean up after the storm, whether anyone from the government helps them or not.
In Spanish, the town's name -- Renacimiento -- means rebirth.